90% of cancer patients die from metastasis. Can hydrogen inhibit cancer metastasis?
Cancer cells have super "metastatic ability", that is, the process in which tumor cells leave the primary lesion, enter blood vessels or lymphatic vessels, re-form cancer cells in appropriate parts of the whole body, and then grow new tumors.
The reason why cancer is terrible is that cancer cells can metastasize. When cancer cells proliferate and spread indefinitely, they will run around in the human body, bringing trouble to other healthy organs. Metastasis is the cause of the final death of more than 90% cancer patients.
Especially recently, a study published by Johns Hopkins University in the United States in the top journal Nature found that cancer cells also "roll in", and even in an environment full of resistance, cancer cells can break through many obstacles and struggle to move.
The metastasis process of cancer cells is divided into cancer cell shedding and finding the metastasis environment.
To capture the whole body, cancer cells must first be able to fall off the primary tumor and survive. First, cancer cells destroy the integrity of the basement membrane (BM), escape from the primary tumor, invade the surrounding extracellular matrix (ECM), and then enter the circulatory system.
Then, cancer cells live as circulating tumor cells (CTC) in the rapidly changing environment, and then as disseminated tumor cells (DTC), invade and settle in distant new organs and tissues;
Finally, with the support of vascular system, cancer cells can grow in ectopic sites. This process is repeated, causing more and more new metastasis and spreading to the whole body.
Different types of cancer cells have their own favorite metastatic pathways, and the organs invaded successively are also different.
Cancer cell metastasis also has a certain priority path, and direct infiltration is the most direct way, as well as lymphatic metastasis and hematogenous metastasis.
Lung cancer: brain → bone → liver metastasis;
Breast cancer: lung → bone, liver → brain metastasis;
Ovarian cancer: abdominal cavity, pelvic cavity → liver, lung and bone metastasis;
Esophageal cancer and colorectal cancer: liver → lung and bone metastasis.
The liver was the first to participate in digestion and metabolism, so it was invaded more preferentially.
Can hydrogen inhibit cancer cell metastasis?
More and more studies have found that reactive oxygen species (ROS) are related to the formation, proliferation, angiogenesis, invasion and distant metastasis of human tumor cells. As we know, hydrogen has a strong antioxidant effect, especially its high selectivity (only neutralizing toxic reactive oxygen radicals), high dispersivity and high safety. Therefore, hydrogen is being studied more and more for cancer prevention and rehabilitation.
Especially with the release of the book Hydrogen Cancer Control, the topic of hydrogen cancer control has been mentioned all the time.
So, can hydrogen inhibit the metastasis of cancer cells?
Existing research shows that hydrogen molecules can play a certain inhibitory role in the development of lymphoma, tongue cancer, colorectal cancer, lung cancer and other cancers.
Studies from Hebei Medical University show that hydrogen can inhibit the proliferation and metastasis of cancer cells, and can also promote cell apoptosis.
A study from Beijing University of Technology found that 6-week hydrogen inhalation can significantly inhibit the growth of ovarian tumors, and the intervention effect of hydrogen molecules on ovarian cancer is due to the inhibition of CSCs cell division and angiogenesis. Wait a minute.
It has been found that under the condition of normal gas, cancer cells proliferate vigorously and move quickly, but under the condition of hydrogen, the proliferation of cancer cells is inhibited, and the cells are enlarged and vacuolated, suggesting degeneration and apoptosis.
Professor Xu Kecheng, a oncologist, said: Hydrogen may have a direct inhibitory effect on cancer cells, but further research is needed; Hydrogen may play a role in controlling cancer mainly by modifying the microenvironment and the whole organism.
From some preliminary studies, we can expect hydrogen to inhibit cancer. But in fact, whether hydrogen can become a cancer intervention means still lacks sufficient evidence-based medical evidence, and further clinical research is needed. At present, it can only be said that it may have such a role and can be tried. Of course, the safety of hydrogen is very high, which is a great advantage of hydrogen application.