Study of the effect of hydrogen water on mitochondria

 Sun Xuejun  2023-05-05 17:00, published in Guangdong

Mitochondria are an organelle present in most cells. They are the structure in the cell that makes energy and the main place where the cell conducts aerobic respiration, called "power house". Its diameter is about 0.5 to 1.0 microns. Mitochondria are the hub of cellular energy metabolism, and they are also important organelles involved in cellular oxidative and inflammatory damage during the disease process. Hydrogen plays a biomedical effect without the role of mitochondria. Among them, there were 12 studies of hydrohydrate medical effect and mitochondrial related study. Some of the studies are summarized here.

More than 10 studies since 2011 have addressed hydrogen and mitochondrial function, mostly in animal disease models, as well as in clinical studies of human disease (Table 19.1). A clinical trial of the mitochondrial effect in humans was published in 2011. The authors conducted an open-label and randomized controlled trial in patients with various mitochondrial myopathy, drinking 1L of hydrogen-rich water daily for 8–12 weeks. Although no objective improvement in clinical symptoms was observed, hydrogen water improved several indicators of mitochondrial function, such as intra-serum lactate and lactate-pyruvate ratio, suggesting that hydrogen water can have an effective effect on mitochondrial dysfunction in a dose-response manner.

Another study evaluated the effect of hydrogen water (0.5-0.6mM) on the allogeneic rat strain. Found that drinking hydrogen water was significantly effective in prolonging heart graft survival and reducing transplanted aortic intimal hyperplasia when compared to grafts treated with conventional water. Hydrogen water treatment is associated with elevated graft ATP levels, and ATP is a key high-energy molecule in cells, produced mainly by mitochondria and accompanied by increased activity of enzymes in the mitochondrial respiratory chain. Hydrogen water lasting for 3 months (1.3ppm) is beneficial for animal models of chemical exposure and mitochondrial function. It can reduce the nephrotoxicity and early tumor-promoting events induced by iron nitrogen triacetate in rats. The effect is to improve mitochondrial dysfunction by inhibiting mitochondrial reactive oxygen species (ROS) formation, enhancing mitochondrial ATP production, and reducing mitochondrial swelling. Drinking hydrogen-rich water (0.6 mM) within 8 weeks protected the damaged hippocampal neurons and neurons in rats. Most of the mitochondria were intact in the hydrogen group, with dark matrix, regular cristae distribution and no signs of mitochondrial swelling. The protective effect of HRW on hepatotoxicity causing subchronic exposure to chlorpyrifos rats was confirmed in a recent trial (Xun et al., 2020), water rich in hydrogen (0.55-0.65 mm) consumption for eight weeks reduces mitochondrial damage and regulates the expression of some oxidative stress-related genes, including the mitochondrial superoxide dismutase 2 (SOD 2) gene. HRW also protects the ER reticulum and mitochondria in mouse liver for acetaminophen-induced hepatotoxicity, drinking water containing dihydrogen-rich water (0.83-0.91 mmol/L) for 5 days against large mitochondria, mitochondrial sequestration, swelling and flocculation (Zhang et al.，2015）。Finally, in methamphetamine-induced neurotoxicity mice, the hydrogen water consumption for 7 days significantly suppressed toxin-induced spatial learning impairment and memory loss, and suppressed mitochondrial dysfunction, neuroinflammation, and ER stress.