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The disease prevention effect of hydrogen is of great significance!

Time : 2022-09-05 Hits : 8

  The significance of this research is to study the preventive effect of hydrogen, which almost completely excludes the direct antioxidant effect of hydrogen, or the classical hypothesis of hydrogen selective antioxidant effect does not play a role here. But surprisingly, hydrogen can prevent severe chemical burns. More importantly, it is found that hydrogen treatment can affect normal corneal cells.


  It is of great significance that hydrogen has a preventive effect. In this way, we can study the physiological effects of hydrogen. In the past, we generally studied the treatment of a certain disease with hydrogen, but the disease itself will produce a series of pathological changes, which are mixed with the effects of hydrogen, making it difficult to distinguish the direct effects of hydrogen. The preventive effect of hydrogen means that hydrogen can produce effects on healthy individuals, such as the phenomenon seen in this study. When the cornea of healthy animals is treated with hydrogen, some biochemical changes can be found, especially the protein and gene expression of PGC-1α, an important signal molecule, are severely affected.This protein is a molecule that affects mitochondrial function, which means that hydrogen may have a great impact on mitochondrial function under physiological conditions. Through this kind of research, we can establish a research paradigm, that is, give animals a certain dose of hydrogen, either short-term or long-term, and then carry out a series of studies on biochemical, metabolic and functional changes of various tissues and organs. This kind of research can study and analyze the physiological effects of hydrogen. Obtaining the physiological effect of hydrogen is of great significance for understanding the biological status of hydrogen and the mechanism of treating diseases with hydrogen.


  From the application point of view, the preventive effect of hydrogen is also of great significance. If the preventive effect is clear, it means that hydrogen can not only treat diseases by anti-oxidation and anti-inflammation, but also achieve the purpose of disease prevention by regulating the body's functions. This is more similar to the effect of exercise and nutrition, and more in line with the concept of health medicine as a tool for disease prevention. Therefore, it is of great significance and value.


  Of course, this kind of effect also makes us consider whether hydrogen has adverse effects on the body, which means that any effective drugs and tools are bound to have the risk of side effects. The influence of hydrogen on physiological function must also have this risk.


  Many studies have proved the therapeutic effect of hydrogen on pathological conditions such as inflammation. However, little is known about the preventive effect of hydrogen. The purpose of this study is to investigate the preventive effect of hydrogen-rich water on alkali burn of cornea in rats. Hydrogen-rich water (hydrogen group) or normal saline (solvent group) was continuously dripped into the cornea of normal rats for 5 min, and then exposed to alkali for 6 h. The corneal epithelial defect area (CED) was measured every 6 hours until 24 hours after alkali exposure. At 6 and 24 hours after injury, samples were taken for histological and immunohistochemical observation, and the mRNA expressions of superoxide dismutase (SOD)1, SOD2 and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) were detected by real-time reverse transcription polymerase chain reaction (RT-PCR). CED at 12 h and inflammatory infiltration cells at 6 h after injury in hydrogen group were significantly less than those in solvent group. In addition, the expression of SOD1 in hydrogen group at 6 h and 24 h was significantly higher than that in solvent group, and the number of pgc -1α positive cells in hydrogen group at 6 h was significantly higher than that in solvent group. However, little is known about its preventive effect. To explore the preventive effect of hydrogen-rich water on corneal alkali burn in rats. Hydrogen-rich water (hydrogen group) or normal saline (solvent group) was continuously dripped into the cornea of normal rats for 5 min, and then exposed to alkali for 6 h. The corneal epithelial defect area (CED) was measured every 6 hours until 24 hours after alkali exposure. At 6 and 24 hours after injury, samples were taken for histological and immunohistochemical observation, and the mRNA expressions of superoxide dismutase (SOD)1, SOD2 and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) were detected by real-time reverse transcription polymerase chain reaction (RT-PCR). CED at 12 h and inflammatory infiltration cells at 6 h after injury in hydrogen group were significantly less than those in solvent group. The expression of SOD1 in hydrogen group was significantly higher than that in solvent group at 6 and 24 h after injury. The number of PGC-1α positive cells in hydrogen group was significantly higher than that in solvent group at 6 h after injury. In this model, preventive perfusion of hydrogen-rich water may inhibit the inflammatory reaction induced by alkali burn by up-regulating the expression of antioxidants such as SOD1 and PGC-1α. Hydrogen not only has therapeutic potential, but also has preventive effect, which may inhibit scar formation after corneal injury and promote wound healing.

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