The role of hydrogen in Covid-19 infection
2019 coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus -2 (SARS CoV-2), which became a new pathogen of global concern in the late 2019. Novel coronavirus (COVID-19) is a highly contagious disease, which can be transmitted by contact between aerosol droplets and body surface. Symptoms and disease severity may vary greatly among individuals, from asymptomatic but infectious people to those who need intensive care. Due to the emergence of novel coronavirus (SARS-CoV-2), the current treatment strategy is not perfect, which depends on the reuse of anti-virus, glucocorticoid, immunosuppressant and oxygen therapy. However, the minimum efficacy of these interventions is worrying. In addition to the epidemic acute infection, it is estimated that as many as 30% of adults infected with COVID-19 will have chronic symptoms lasting more than 12 weeks. It is estimated that 15% of children aged 2 ~ 16 have long-term sequelae related to SARS-CoV-2 infection.
According to recent clinical data, hydrogen molecule (hydrogen) and oxygen-hydrogen (hydrogen /O2) therapy have successfully repaired the weakening effect of SARS-CoV-2 infection on adults. As an effective anti-inflammatory and antioxidant, hydrogen can promote rehabilitation by reducing excessive inflammatory cytokine cascade reaction and reducing inhalation resistance in patients with mild to moderate disease symptoms.
In this review, the author studied the clinical and empirical evidence related to the treatment of acute and chronic COVID-19 symptoms with hydrogen-containing therapy.
Molecules are paired aggregates of atomic hydrogen (H). Medical research on hydrogen shows many beneficial effects, including anti-apoptosis, analgesic, anti-inflammatory and antioxidant properties, which suggests that hydrogen may have advantages in the treatment of COVID-19 and other inflammation-related diseases. Hydrogen is a gaseous substance, so it can be easily incorporated into biological functions. Hydrogen is a diatomic molecule with a molecular weight of 2.016 g/mol, nonpolar and electrochemically neutral. Because of these characteristics, the distribution of hydrogen on phospholipid membrane is not affected by electrochemical gradient or hydrophilic-hydrophobic force. Therefore, hydrogen can greatly affect the reaction in cytoplasm and the reaction in discrete cell cavities including organelles (such as mitochondria). With more and more laboratory and clinical studies confirming the safety and effectiveness of hydrogen-containing therapy, the research of hydrogen as an interventional therapy for a wide range of infectious and non-infectious diseases is developing rapidly.
As a medicine, hydrogen has many uses, because the gas can be administered in various ways, including inhaling gas alone or mixed with other gases; Infusion of hydrogen-rich saline (HRS); Intake of hydrogen-rich water; Or local applications. We are still learning about the influence of SARS-CoV-2 infection. Therefore, this review analyzes the recent scientific literature on the evolution of SARS-CoV-2 and the different symptoms of COVID-19 post-syndrome, and provides a possible and effective solution for the serious consequences of acute COVID-19 and the long-term complications that may occur from it. Due to this simple and diverse application method, people's interest in hydrogen therapy has increased rapidly. The objective analysis of hydrogen medicine in the past 15 years strongly shows that hydrogen is a significant and effective anti-inflammatory and antioxidant compound. Therefore, the author makes an hermeneutic exposition on whether the emerging virus pedigree may affect the duration and severity of COVID-19, and how hydrogen therapy can be used for symptomatic treatment of acute COVID-19 and post-COVID-19 syndrome.