In the past, there was no clear research evidence to support the effect of hydrogen on hypertension. A study in the School of Pharmacy of Second Military Medical University once found that injecting hydrogen saline into animals with spontaneous hypertension could not reduce blood pressure, but could reduce the damage of blood vessels and organs caused by hypertension. This seems to give people a kind of comfort, that is, although hydrogen can’t reduce blood pressure, it is also of great significance to reduce the damage of target organs.
However, the experimental results that can’t reduce hypertension are also embarrassing, because we have always emphasized that hydrogen has antioxidant and anti-inflammatory effects, and inflammation and oxidative damage are also the key factors involved in the formation of hypertension, which can play a role in dyslipidemia and arteriosclerosis. How to treat hypertension, a metabolic disease with chronic inflammation, can’t be effective?
These studies also lead us to generally not recommend clinical trials of hypertension, but the incidence of hypertension is almost one of the highest among all chronic diseases. If hydrogen has no effect on hypertension, it is a pity that this star molecule with broad-spectrum biological effects. However, the information provided by many cases shows that the blood pressure of hypertensive patients who insist on drinking hydrogen water and inhaling hydrogen for a long time will gradually decrease, and some hypertensive patients even have hypotension because they take drugs at the same time. Of course, in some cases, it was found that in the early stage of hydrogen use, blood pressure did not decrease but increased. Research related to hypertension shows that hydrogen can reduce the proportion of hypertension drugs used by uremic patients.
In December, 2020, Scientific Report published a report from the Medical College of Keio University in Japan, which studied hypertension caused by nephrectomy, mainly hoping to study renal hypertension. Inhalation of 1.3% hydrogen every day for 1 hour and continuous treatment for 4 weeks can significantly lower blood pressure, and even after 3 weeks of nephrectomy, inhalation of hydrogen still shows a certain effect.
The basis of hydrogen treatment for hypertension was further studied, and it was found that hydrogen inhalation could inhibit the hyperactive sympathetic nervous system and enhance the activity of parasympathetic nervous system, so that the out-of-balance autonomic nerve could regain its balance.
The authors believe that inflammation-related injuries may affect autonomic nerve function through the brain, leading to increased sympathetic nerve excitability, decreased parasympathetic nerve activity, and increased blood pressure. Hydrogen treatment can stabilize the inflammatory reaction in the brain, promote the balance of autonomic nerve, and achieve the purpose of reducing hypertension.
This research provides an important foundation for the future clinical research of hydrogen therapy for hypertension. Because the incidence of hypertension is very high, and the diagnosis of hypertension is relatively objective, it can also be analyzed by non-invasive techniques, especially in combination with wearable devices to collect related data such as heart rate, which is very beneficial to analyze the effect of hydrogen.
Considering the position of autonomic nerve in blood pressure control, human research can also be combined with this test.
This research provides an important foundation for the future clinical research of hydrogen therapy for hypertension. Because the incidence of hypertension is very high, and the diagnosis of hypertension is relatively objective, it can also be analyzed by non-invasive techniques, especially in combination with wearable devices to collect related data such as heart rate, which is very beneficial to analyze the effect of hydrogen. Considering the position of autonomic nerve in blood pressure control, human research can also be combined with this test.
The inhaled hydrogen used in the study is 1.3%, which is a very low hydrogen dose, roughly equivalent to 100-200ml of hydrogen inhalation per minute. When conducting human experiments, it is safe and simple to use about 300ml of pure hydrogen inhalation as the hydrogen supply method. I hope to see the results of this clinical trial published soon.
Results: Hydrogen reduced systolic blood pressure and mean arterial blood pressure, but had no effect on diastolic blood pressure.
Abstract: A recent clinical study shows that hemodialysis with hydrogen-containing dialysate can improve the blood pressure control of patients with end-stage renal disease. Here, we studied whether hydrogen has beneficial effects on hypertension in animal models. We asked the 5/6 nephrectomized rats to inhale the gas mixture of hydrogen (1.3% hydrogen+21% oxygen+77.7% nitrogen) or control group (21% oxygen+79% nitrogen) for 1 hour every day. Hydrogen inhalation can significantly inhibit the increase of blood pressure after 5/6 nephrectomy. The antihypertensive effect of hydrogen was also confirmed in rats with stable hypertension 3 weeks after nephrectomy. In order to check the detailed effect of hydrogen on hypertension, the study used an implantable telemetry system to continuously monitor blood pressure.
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Results It was found that hydrogen not only had antihypertensive effect during daytime rest, but also had antihypertensive effect during nighttime activities. The analysis of blood pressure spectrum shows that hydrogen can improve the imbalance of autonomic nervous system by inhibiting the overactive sympathetic nervous system and enhancing the activity of parasympathetic nervous system. These effects occur at the same time as lowering blood pressure. In a word, in the animal model of hypertension, exposure to hydrogen for 1 hour every day has antihypertensive effect.